I-Mu-conotoxin CnIlIC, eyaziwa nangokuthi i-conotoxin CnIlIC, iyi-peptide eyenzeka ngokwemvelo etholakala ebuhlungwini bomnenke wasolwandle i-Conus conus.Le peptide iye yathola ukunakwa okukhulu phakathi neminyaka ngokusetshenziswa kwayo okungenzeka kwezimonyo.I-Mu-conotoxin CnIlIC iye yacwaningwa ngemiphumela yayo ebalulekile esikhumbeni, futhi amandla ayo ekwakhiweni kwezimonyo ayahlolwa ukuze akwazi ukwenza ngcono.
ukubukeka kwesikhumba kanye nokulwa nokuguga.
Ukusetshenziswa kwe-Mu-conotoxin CnIlIC ezimonyoni kugxile ekhonweni layo lokunciphisa ukubukeka kwemigqa emihle nemibimbi, ukuthuthukisa ukuthungwa kwesikhumba, nokukhuthaza ibala lobusha nelikhazimulayo.Le peptide isebenza ngokukhomba ama-receptors athile esikhunjeni, ekugcineni ibangele imisipha yobuso ukuthi ikhululeke futhi inciphise ukufinyela kwemisipha okuholela ekwakhekeni kwemibimbi.
Enye yezinzuzo ezinkulu ze-Mu-conotoxin CnIlIC amandla ayo okusebenza njengesiphumuli semisipha lapho isetshenziswa phezulu.Ngokuvimbela ukukhululwa kwe-acetylcholine ekuhlanganeni kwe-neuromuscular, le peptide inciphisa ngempumelelo ukunyakaza kwemisipha okuphindaphindayo okubangela imibimbi eguquguqukayo njengezinyawo zegwababa, imigqa eshwabene, kanye nemibimbi yasebunzini.Ngakho-ke, ukusetshenziswa njalo kwe-Mu-conotoxin CnIlIC ekwenziweni kwezimonyo kungaholela esikhumbeni esibushelelezi, esibukeka sisincane.
Ukwengeza, i-Mu-conotoxin CnIlIC iboniswe ukuthi ikhuthaze ukukhiqizwa kwe-collagen ne-elastin esikhumbeni.Lawa maprotheni abalulekile ekulondolozeni ukunwebeka kwesikhumba nokuqina, futhi ukuncipha kwawo kuyisici esivamile enqubweni yokuguga.Ngokuphromotha i-collagen ne-elastin synthesis, i-Mu-Conotoxin CnIlIC isiza ukuthuthukisa ithoni yesikhumba, yehlise ukuwohloka, futhi ithuthukise ukuthungwa kwesikhumba okuphelele ukuze kubukeke kobusha, nokuthambile.
Ngaphezu kwezakhiwo zayo zokulwa nokuguga, i-Mu-conotoxin CnIlIC iphinde ibe namandla okubhekana nokunye okukhathazayo kwesikhumba, okufana ne-hyperpigmentation kanye nebala lesikhumba elingalingani.Ucwaningo lubonisa ukuthi le peptide ilawula ukukhiqizwa nokusatshalaliswa kwe-melanin, okuholela esikhumbeni esilinganayo nesikhazimulayo.Ngokulawula umbala kanye nokunciphisa ukwakheka kwamachashazi amnyama, i-Mu-Conotoxin CnIlIC isiza ekudaleni ibala elicacile nelikhanyayo.
Ukusetshenziswa kwe-Mu-conotoxin CnIlIC ezimonyoni kuvula indlela yokuthuthukiswa kwemikhiqizo emisha yokunakekelwa kwesikhumba, okuhlinzeka ngezixazululo ezithuthukisiwe zezinguquko zesikhumba ezihlobene nobudala.Kusukela kuma-serum nokhilimu kuya kumamaski nokwelashwa, amafomula ezimonyo aqukethe le peptide aklanyelwe ukukhomba izimpawu eziningi zokuguga futhi anikeze izinzuzo eziphelele zokunakekelwa kwesikhumba.
Ngokuphawulekayo, ukusetshenziswa kwe-Mu-conotoxin CnIlIC ezimonyoni kusekelwa ukuhlolwa okuqinile nokuhlolwa kokuphepha ukuze kuqinisekiswe ukusebenza kwayo nokubekezelelana.Izinkampani zezimonyo nezingcweti zokunakekelwa kwesikhumba ziyaqhubeka nokwenza ucwaningo nezivivinyo zomtholampilo ukuze ziqhubeke zihlola amandla ale peptide futhi zicwengisise ukusetshenziswa kwayo ekwakhiweni kokunakekelwa kwesikhumba.
Kafushane, i-Mu-conotoxin CnIlIC inamathemba abanzi emkhakheni wezimonyo, ihlinzeka ngendlela entsha yokubhekana nokuguga kwesikhumba nokuthuthukisa ikhwalithi yesikhumba iyonke.Njengoba ucwaningo nentuthuko kulo mkhakha iqhubeka nokuthuthuka, kulindeleke ukuthi imikhiqizo eminingi yokunakekelwa kwesikhumba equkethe i-Mu-conotoxin CnIlIC izovela ngenxa yemiphumela yayo ebalulekile yokusetshenziswa.Ngamandla ayo okunciphisa imibimbi, ukuthuthukisa ukuthungwa kwesikhumba nokukhuthaza ibala elikhazimulayo, i-Mu-Conotoxin CnIlIC ithembisa ukushintsha indlela esibhekana ngayo nokunakekelwa kwesikhumba esilwa nokuguga futhi iphakamise izinga lokwakheka kwezimonyo eminyakeni ezayo.
Isikhathi sokuthumela: Dec-22-2023